# Standard Operating Procedure: [Title]

| Document ID | SOP-XXX |
|-------------|---------|
| Title | [Title] |
| Revision | 1.0 |
| Effective Date | [DATE] |
| Author | [AUTHOR] |
| Approved By | [APPROVER] |
| Department | Genetics & Genomics Laboratory |

---

## 1. Purpose

[State the purpose of this procedure]

## 2. Scope

[Define the scope and applicability - e.g., germline testing, somatic testing, specific genes/panels]

## 3. Responsibilities

### 3.1 Laboratory Director
- [Responsibility]
- [Responsibility]

### 3.2 Clinical Molecular Geneticist
- [Responsibility]
- [Responsibility]

### 3.3 Genetic Counselor
- [Responsibility]
- [Responsibility]

### 3.4 Bioinformatician
- [Responsibility]
- [Responsibility]

### 3.5 Laboratory Technologist
- [Responsibility]
- [Responsibility]

## 4. Definitions

| Term | Definition |
|------|------------|
| ACMG | American College of Medical Genetics and Genomics |
| AMP | Association for Molecular Pathology |
| VAF | Variant Allele Frequency |
| VUS | Variant of Uncertain Significance |
| NGS | Next-Generation Sequencing |
| SNV | Single Nucleotide Variant |
| CNV | Copy Number Variant |
| [Term] | [Definition] |

## 5. Procedure

### 5.1 [Section Title]

[Procedure steps]

### 5.2 [Section Title]

[Procedure steps]

## 6. Quality Control

- [QC checkpoints]
- [Acceptance criteria]
- [Monitoring procedures]

## 7. Related Documents

- [List related procedures, forms, etc.]
- Example: SOP-VI-001: ACMG/AMP Variant Classification
- Example: FRM-VC-001: Variant Classification Worksheet

## 8. References

### Regulatory References
- CAP Molecular Pathology Checklist
- CLIA regulations for high-complexity testing
- [Applicable state regulations]

### Professional Guidelines
- ACMG/AMP Standards and Guidelines for the Interpretation of Sequence Variants (2015)
- ACMG Secondary Findings Recommendations (SF v3.2)
- [Other applicable guidelines]

### Scientific Literature
- [Key publications]
- [Evidence base]

---

## Revision History

| Rev | Date | Description | Author |
|-----|------|-------------|--------|
| 1.0 | [DATE] | Initial release | [AUTHOR] |